|
T6588 |
Mitoxantrone
|
mitozantrone |
Topoisomerase
,
PKC
|
|
Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisome... |
|
T0158 |
Mitoxantrone dihydrochloride
|
Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride |
Topoisomerase
,
PKC
|
|
Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor. |
|
T12783 |
RWJ 50271
|
|
Integrin
|
|
RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 μM in HL60 cells). |
|
T14946 |
Ch55
|
Ch-55,CH 55,3,5-Di-tert-butylchalcone |
Retinoid Receptor
|
|
Ch55 (3,5-Di-tert-butylchalcone) is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors. Ch55 can be used in studies about cancer. |
|
T36963 |
CAY10503
|
|
|
|
CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503 inhibits the growth of HL60, multidrug resistant HL60R, and K562 cells with IC50 values of... |
|
T60559 |
S-(N-PhenethylthiocarbaMoyl)-L-cysteine
|
|
|
|
S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys) is an anticarcinogenic agent. S-(N-PhenethylthiocarbaMoyl)-L-cysteine shows antileukemic activity which inhibits DNA synthesis in HL60 cells [1]. S-(N-Phenethylthiocarb... |
|
T10971 |
DC10SMe
|
|
Others
|
|
DC10SMe is a DNA alkylating agent that can be used in the synthesis of antibody-drug conjugates (ADC). The IC50 of DC10SMe for Ramos, Namalwa and HL60 / s cancer cells were 15 pM, 12 pM and 12 pM, respectively. |
|
T63957 |
PI3K-IN-29
|
|
|
|
PI3K-IN-29, a potent inhibitor of PI3K, exhibits substantial inhibition capabilities against U87MG, HeLa, and HL60 cells, with IC50 values of 0.264, 2.04, and 1.14 µM, respectively. It effectively blocks the PI3K/Akt sig... |
|
T78068 |
O-allylvanillin
|
|
Others
|
|
O-Allylvanillin, an O-allylchalcone derivative, exhibits anti-cancer properties by inhibiting the growth of THP-1, HL60, Hep-G2, and MCF-7 cells with IC50 values of 74.76 μM, 63.52 μM, 90.99 μM, and 90.11 μM, respectivel... |
|
T10975 |
DC44SMe
|
|
Others
|
|
The IC50 of DC44SMe for Ramos, Namalwa and HL60 / s cancer cells was 2.0 nM, 2.8 nM and 1.9 nM, respectively. DC44SMe can be used for targeted treatment of cancer. DC44SMe is a phosphate prodrug of DC44 and can be used i... |
|
T10976 |
DC4SMe
|
|
Others
|
|
The IC50s of DC4SMe on Ramos, Namalwa and HL60 / s cancer cells were 1.9 nM, 2.9 nM and 1.8 nM, respectively. DC4SMe can be used for targeted therapy of tumors. DC4SMe is a phosphate prodrug of the cytotoxic DNA alkylati... |
|
T79478 |
Anti-inflammatory agent 45
|
|
Apoptosis
|
|
Compound 2v (Anti-inflammatory agent 45) demonstrates anticancer properties with direct inhibitory impacts on the proliferation of various blood malignancies, such as leukemia, lymphoma, and myeloma cell lines. It induce... |
|
T10969 |
DC1SMe
|
|
Others
|
|
DC1 is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065. DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer. DC1Sme is a DC1 derivative with IC50 ... |
|
T79683 |
HDAC/CD13-IN-1
|
|
Others
|
|
HDAC/CD13-IN-1 (Compound 12) is an inhibitor of both HDAC and CD13, with IC50 values of 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μM for HDAC1, HDAC2, and HDAC3, respectively. This compound ef... |
|
T78854 |
WK499
|
|
|
|
BCL6-IN-10 (Compound WK499) is an inhibitor of BCL6, disrupting its interaction with the SMRT protein and promoting apoptosis, cell cycle arrest, and DNA damage. It effectively hampers the proliferation of various AML ce... |
